Aminobenzoic acids and derivatives
Apexbio Technology LLC Danofloxacin Mesylate 119478-55-6 1g
Danofloxacin Mesylate (119478-55-6) is a small-molecule inhibitor targeting bacterial DNA gyrase and topoisomerase IV It is designed to inhibit these enzymes thereby impeding bacterial DNA replication and transcription Danofloxacin Mesylate exerts its biological activity primarily through inhibition of bacterial DNA gyrase and topoisomerase IV In microbiological assays Danofloxacin demonstrates antibacterial inhibition with a minimum inhibitory concentration (MIC90) of approximately 0 28 M Based on these pharmacological properties Danofloxacin Mesylate holds research potential in veterinary antimicrobial studies investigation of bacterial resistance mechanisms and comparative evaluation of antimicrobial activity
Medchemexpress LLC Lomitapide mesylate | 202914-84-9 | 99.6% | 789.83 | 50 MG
Lomitapide mesylate is a highly effective MTP protein inhibitor. It has an in vitro IC50 value of 8nM.
- Highly effective MTP protein inhibitor
- In vitro IC50 value of 8nM
Medchemexpress LLC Saquinavir mesylate | 149845-06-7 | 99.8% | 766.95 | 5 MG
Saquinavir mesylate (Ro 31-8959) is an orally active HIV protease inhibitor used in AIDS research. It also demonstrates anti-inflammatory activity and induces apoptosis of human red blood cells.
- Orally active HIV protease inhibitor
- Used in AIDS research
- Has anti-inflammatory activity
- Induces apoptosis of human red blood cells
- Exhibits anti-HIV activity in the thy/liv-SCID-hu mouse model
- Has a protective effect in the mouse model of lung injury induced by hepatic ischemia-reperfusion (I/R)
Medchemexpress LLC Saquinavir mesylate | 149845-06-7 | 99.8% | 766.95 | 100 MG
Saquinavir mesylate is an orally active HIV protease inhibitor. It is used in AIDS research and exhibits anti-inflammatory activity, capable of inducing apoptosis in human red blood cells.
- Orally active HIV protease inhibitor
- Used in AIDS research
- Possesses anti-inflammatory activity
- Induces apoptosis of human red blood cells
- Exhibits anti-HIV activity in mouse models
- Protective effect in mouse models of lung injury
Apexbio Technology LLC Bromocriptine mesylate 22260-51-1 10mM (in 1mL DMSO)
Bromocriptine mesylate (CAS 22260-51-1) is a selective agonist of D -like dopamine receptors exhibiting high affinity with a pKi of 8 05 0 2 Through modulation of D receptor activity bromocriptine mesylate influences metabolic processes by reducing glucose intolerance and insulin resistance inhibits pituitary prolactin secretion and enhances motor function relevant to Parkinson s disease The compound has established applications in research on metabolic disorders neuroendocrine regulation and neurodegenerative diseases including studies pertaining to type 2 diabetes prolactinomas acromegaly and Parkinson s disease
TARGETMOL CHEMICALS INC Nafamostat mesylate 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Purity 97.36%
Apexbio Technology LLC Safinamide Mesylate 202825-46-5 500mg
Safinamide Mesylate (CAS 202825-46-5) is the mesylate salt form of safinamide a selective and reversible inhibitor of monoamine oxidase B (MAO-B) Safinamide exhibits an IC50 of 98 nM for MAO-B inhibition leading to enhanced dopaminergic transmission by reducing dopamine degradation In addition to MAO-B inhibition safinamide modulates sodium and calcium channels (IC50 8 2 M and 31 5 M respectively) and suppresses glutamate release ( 56 4 M) contributing to its anticonvulsant properties Research applications include the study of Parkinson s disease mechanisms and the investigation of dopaminergic and glutamatergic modulation
Medchemexpress LLC Ibutamoren Mesylate | 159752-10-0 | 99.83% | C28H40N4O8S2 | 50 MG
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. It is an orally active growth hormone (GH) secretagogue.
- Potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
- Orally active growth hormone (GH) secretagogue.
- Increases body weight gain and increases serum IGF-1 and GH levels in dogs (at 5 mg/kg/day).
- Chronic oral administration increases and maintains elevated IGF-I levels.
- Significantly increases peak GH concentrations after oral administration.
- Induces an immediate, large, long-lasting increase in GH levels when administered orally or i.v.
Medchemexpress LLC Saquinavir mesylate | 149845-06-7 | 99.8% | 766.95 | 50 MG
Saquinavir mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. It also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
- Orally active HIV protease inhibitor.
- Can be used in the research of AIDS.
- Has anti-inflammatory activity.
- Can induce apoptosis of human red blood cells.
Apexbio Technology LLC Phentolamine Mesylate 65-28-1 10mM (in 1mL DMSO)
Phentolamine Mesylate (CAS 65-28-1) is a non-selective alpha-adrenergic antagonist that blocks both alpha 1- and alpha 2-adrenoreceptors By preferentially inhibiting presynaptic alpha 2-adrenoreceptors phentolamine increases the release of neurotransmitters such as noradrenaline leading to enhanced functional biological modulation (FBM) while also exerting effects on postsynaptic alpha 1-adrenoreceptors This dual antagonism makes phentolamine a valuable tool for investigating adrenergic signaling pathways neurotransmitter regulation and vascular tone in various biomedical research settings
Medchemexpress LLC Purinostat mesylate | 2650188-32-0 | 99.5% | 586.62 | 25 MG
Purinostat mesylate is a selective inhibitor of HDAC. It inhibits class I and class IIb HDACs with IC50s ranging from 0.81 to 11.5 nM. It induces apoptosis and affects the cell cycle of LAMA84 and 188 BL-2 cells, showing potent anti-leukemia effects in vivo. It is used for research on lymphoblastic leukemia.
- Inhibits class I and class IIb HDACs
- Induces apoptosis and affects cell cycle of LAMA84 and 188 BL-2 cells
- Suppresses leukemia progression in vivo
- Demonstrates potent anti-leukemia effects in BCR-ABL(T315I)-induced primary B-ALL mice
Apexbio Technology LLC Delavirdine mesylate 147221-93-0 200mg
Delavirdine mesylate (CAS 147221-93-0) is a small-molecule inhibitor targeting HIV-1 reverse transcriptase It is designed to selectively inhibit the enzymatic activity of HIV-1 reverse transcriptase thereby disrupting viral DNA synthesis and impeding HIV replication Delavirdine mesylate exerts its biological activity primarily through direct binding to an allosteric site on HIV-1 reverse transcriptase In biochemical studies delavirdine mesylate demonstrates inhibitory activity against HIV-1 reverse transcriptase with an IC50 value of 0 26 M Based on these pharmacological properties delavirdine mesylate holds research potential in antiviral assays HIV resistance studies and mechanistic investigations into NNRTI-related enzyme inhibition
Medchemexpress LLC Pradefovir mesylate | 625095-61-6 | 99.5% | 519.90 | 10 MG
Pradefovir mesylate is a cyclodiester prodrug of PMEA, designed for efficient and specific activation by CYP3A4, an enzyme mainly located in the liver. It serves as a good substrate for liver CYP3A4 and is converted to PMEA in human liver microsomes.
- Good substrate for liver CYP3A4
- Converted to PMEA in human liver microsomes
- Designed for activation through an oxidative reaction
- Does not act as a CYP inducer in rats
Apexbio Technology LLC Danofloxacin Mesylate 119478-55-6 5g
Danofloxacin Mesylate (119478-55-6) is a small-molecule inhibitor targeting bacterial DNA gyrase and topoisomerase IV It is designed to inhibit these enzymes thereby impeding bacterial DNA replication and transcription Danofloxacin Mesylate exerts its biological activity primarily through inhibition of bacterial DNA gyrase and topoisomerase IV In microbiological assays Danofloxacin demonstrates antibacterial inhibition with a minimum inhibitory concentration (MIC90) of approximately 0 28 M Based on these pharmacological properties Danofloxacin Mesylate holds research potential in veterinary antimicrobial studies investigation of bacterial resistance mechanisms and comparative evaluation of antimicrobial activity